Publications

Guillette, T.C., James McCord, Matthew Guillette, M.E. Polera, Kyle T. Rachels, Clint Morgeson, Nadine Kotlarz, Detlef R.U. Knappe, Benjamin J. Reading, Mark Strynar, Scott M. Belcher. (2020) Elevated levels of per- and polyfluoroalkyl substances in Cape Fear River Striped Bass (Morone saxatilis) are associated with biomarkers of altered immune and liver function. Environment International 136, 105358. DOI: doi.org/10.1016/j.envint.2019.105358.

  • PFOS was detected in all samples and had elevated levels in Cape Fear River fish.
  • Cape Fear River fish had detectable levels of a novel PFAS (Nafion byproduct 2).
  • PFOS positively associated with higher lysozyme activity in Cape Fear River fish.
  • Cape Fear River fish have 40 times higher PFAS body burden than a reference site.

 

Jackson, T..J., Gabriel A. Bendfeldt, Kelby A. Beam, Kylie D. Rock, Scott M. Belcher. (2020) Heterozygous mutation of sonic hedgehog receptor (Ptch1) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice. Neurotoxicology and Teratology 78, 106866. DOI: doi.org/10.1016/j.ntt.2020.106866.

  • Dysregulation of sonic hedgehog (SHH) signaling caused cerebellar and cortical neuron overgrowth.
  • Haploinsufficiency of the SHH receptor Patched (Ptch1+/−) altered activity and social behavior in adult females.
  • Activity and behavior were not impacted in male Ptch1+/− mutant mice.
  • Haploinsufficiency of PTCH caused cerebellar neuron overgrowth in lobules IV/V and IX of both sexes.
  • Hippocampal structure and cellularity of the isocortex were altered in Ptch1+/− females, but not males.