A Critical Review and Meta-analysis of Impacts of Per- and Polyfluorinated Substances (PFAS) on the Brain and Behavior
Hannah M. Starnes, Kylie D. Rock, Thomas W. Jackson, Scott M. Belcher (2022)
Frontiers in Toxicology
Blood Concentrations of Per- and Polyfluoroalkyl Substances are Associated with Lupus-like Autoimmunity in the American Alligator
Theresa C. Guillette, Thomas W. Jackson, Matthew Guillette, James McCord, Scott M. Belcher (2022)
Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances (PFAS)
Kaylie I. Kirkwood, Jonathon Fleming, Helen Nguyen, David M. Reif, Erin S. Baker, Scott M. Belcher (2022)
Environmental Science & Technology 56 (6), 3441-3451
Rapid Characterization of Human Serum Albumin Binding for Per- and Polyfluoroalkyl Substances Using Differential Scanning Fluorimetry
Thomas W. Jackson, Chris M. Scheibly, Madi E. Polera, Scott M. Belcher (2021)
Environmental Science & Technology 55 (18), 12291-12301
Elevated Levels of Per- and Polyfluoroalkyl Substances in Cape Fear River Striped Bass (Morone saxatilis) are Associated with Biomarkers of Altered Immune and Liver Function
Guillette, T.C., James McCord, Matthew Guillette, M.E. Polera, Kyle T. Rachels, Clint Morgeson, Nadine Kotlarz, Detlef R.U. Knappe, Benjamin J. Reading, Mark Strynar, Scott M. Belcher (2020) Environment International 136, 105358
- PFOS was detected in all samples and had elevated levels in Cape Fear River fish.
- Cape Fear River fish had detectable levels of a novel PFAS (Nafion byproduct 2).
- PFOS positively associated with higher lysozyme activity in Cape Fear River fish.
- Cape Fear River fish have 40 times higher PFAS body burden than a reference site.
Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring
Thomas W. Jackson, Garret L. Ryherd, Chris M. Scheibly, Aubrey L. Sasser, Theresa C. Guillette, Scott M. Belcher (2020)
Toxicological Sciences 178 (2), 264-280
Heterozygous mutation of sonic hedgehog receptor (Ptch1) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice
Jackson, T.W., Gabriel A. Bendfeldt, Kelby A. Beam, Kylie D. Rock, Scott M. Belcher. (2020)
Neurotoxicology and Teratology 78, 106866
- Dysregulation of sonic hedgehog (SHH) signaling caused cerebellar and cortical neuron overgrowth.
- Haploinsufficiency of the SHH receptor Patched (Ptch1+/−) altered activity and social behavior in adult females.
- Activity and behavior were not impacted in male Ptch1+/− mutant mice.
- Haploinsufficiency of PTCH caused cerebellar neuron overgrowth in lobules IV/V and IX of both sexes.
- Hippocampal structure and cellularity of the isocortex were altered in Ptch1+/− females, but not males.